Hydrophobization of Polyanio nic Polymers to Achieve Higher Biological Activity

Raphael M. Ottenbrite Virginia Commonwealth University, Richmond, Virginia

Yasuo Suda Osaka University, Osaka, Japan

I. INTRODUCTION

Since the pioneer work by Merigan in 1967 [l], many kinds of synthetic or natural polyanionic polymers have been examined for their biological activities [2-8], such as cytotoxicity, antiviral activity, antitumor activity, and immunomodulating activity. Although the biological results were interesting, the extent of activity for clinical application was still low.