ABSTRACT
NCI CARC TRS 128 DHEW PUB NO 79-1383 GIVEN BY GAVAGE IN THIS BIOASSAY, ADMINISTRATION OF THE COMPOUND WAS CARCINOGENIC TO FISCHER 344 RATS, CAUSING NEOPLASMS OF THE SKIN (EXCLUDING SKIN OF THE EAR) IN MALES, ENDOMETRIAL STROMAL POLYPS IN FEMALES AND LEUKEMIA AND MALIGNANT LYMPHOMA IN BOTH SEXES. THE COMPOUND WAS ALSO ASSOCIATED WITH THE DEVELOPMENT OF A COMBINATION OF SQUAMOUS-CELL CARCINOMAS AND SEBACEOUS ADENOCARCINOMAS OF THE ZYMBAL GLAND AND SKIN OF THE EAR IN RATS OF BOTH SEXES. THERE WAS NO EVIDENCE FOR THE CARCINOGENICITY OF THE COMPOUND IN B6C3Fl MICE.
