ABSTRACT
EPA TSCA 8(E) 1088-0755 OCT 88 ELI LILLY REPORTED THREE MALE EMPLOYEES WITH SYMPTOMS COMPATffiLE WITH HYPOXIA; TWO DIAGNOSED WITH METHEMOGLOBINEMIA; OBTAINEDWHILEPREPARING PESTICIDECONTAINING MONOLINURON AND ETHALFLURALIN. COPY OF HOECHST A.G. DATA SHEET FOR MONOLINURON PROVIDED: ORAL LDSO: 1800 MG/KG (RAT), DERMAL LD50: 1500 MG/KG (FEMALE RAT); NONIRRITANT IN DERMAL AND EYE TESTS (RABBIT). PESTICIDE
REPORT 01
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REPORT06
REPT'D USE
IARC MONOGRAPH 12 1976 IN ONE STUDY BY ORAL ADMINISTRATION IN MICE, AN INCREASED INCIDENCE OF LUNG TUMORS WAS OBSERVED IN MALES OF ONE OF TWO STRAINS. IN ONE STUDY BY ORAL ADMINISTRATION IN MALE RATS, TUMORS WERE OBSERVED AT VARIOUS SITES; NONE WERE OBSERVED IN CONCURRENT CONTROLS. THE AVAILABLE DATA SUGGEST THAT MONURON IS CARCINOGENIC.
