ABSTRACT
IARC MONOGRAPH 37 SEP 85 TESTED FOR CARCINOGENICITY BY ORAL ADMINISTRATION IN TWO STRAINS OF RATS AND BY SUBCUTANEOUS INJECTION IN HAMSTERS. IN RATS, INDUCED OESOPHAGEAL CARCINOMAS AND/OR PAPILLOMAS. STUDY IN HAMSTERS INADEQUATE FOR EVALUATION. THUS LIMITED EVIDENCE FOR CARCINOGENICITY OF N-NITROSOANABASINE TO EXPERIMENTAL ANIMALS. LABORATORY CHEMICAL AND FOUND IN TOBACCO PRODUCTS AND SMOKE
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!ARC MONOGRAPH 37 SEP 85 NATTESTEDFORCARCINOGENICITYBYSUBCUTANEOUSINJECTION IN RATS OF ONE STRAIN AT THREE DOSE LEVELS. THERE WAS NO INCREASE IN TUMOR INCIDENCE. THUS, DATA ARE INADEQUATE TO EVALUATE CARCINOGENICITY OF N'-NITROSOANATABINE TO EXPERIMENTAL ANIMALS. LABORATORY CHEMICAL
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IARC MONOGRAPH 17 1978 DBNA IS CARCINOGENIC IN ALL ANIMAL SPECIES TESTED: MICE, RATS, SYRIAN GOLDEN, CHINESE AND EUROPEAN HAMSTERS, RABBITS AND GUINEA-PIGS, AFTER ITS ORAL, SUBCUTANEOUS, INTRAPERITONEAL OR INTRA VENOUS ADMINISTRATION. IT PRODUCES BENIGN AND MALIGNANT TUMORS IN THE URINARY BLADDER, ESOPHAGUS, LIVER, RESPIRATORY TRACT, STOMACH AND INTESTINE, AND ALSO LEUKEMIA; IT IS PARTICULARLY EFFECTIVE AS A BLADDER CARCINOGEN. IT IS CARCINOGENIC FOLLOWING ITS ADMINISTRATION PRENATALLY AND IN SINGLE DOSES. 1979 SUPPLEMENT/SUFFICIENT EVIDENCE FOR ANIMAL CARCINOGENICITY.
