ABSTRACT
IARC MONOGRAPH 13 1977 PRONETALOL HYDROCHLORIDE IS CARCINOGENIC IN MICE FOLLOWING ITS ORAL ADMINISTRATION: IT PRODUCED THYMIC LYMPHOMAS. ANDRENERGIC-BLOCKING AGENT
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EPA TSCA 8(E) 0186-0585 JAN 86 CffiA-GEIGY SUBMITTED RESULTS FROM A 28 DAY GAVAGE STUDY IN RATS THAT INDICATED A POTENTIAL IMMUNOSUPPRESSIVE ACTIVITY: SIX GROUPS OF 10 RATS EACH RECEIVED DAILY DOSES OF 0, 60, 100, 300, 600 AND 1000 MG/KG. ALL DOSE LEVELS PRODUCED ALTERATIONS IN WHITE BLOOD CELL PARAMETERS, THYMUS WEIGHT PLUS LESIONS IN THE SPLEEN, LYMPH NODES AND LIVER. AUTOMATIVE COATINGS AND POLYPOPYLENE FILMS
REPORT 01 NCI SUMMARY DEC 75 ORAL ADMINISTRATION OF THE COMPOUND AS AN AQUEOUS SOLUTION TO RATS RESULTED IN MALIGNANT TUMORS. RATS AND MICE ADMINISTERED THE CHEMICAL BY SUBCUTANEOUS AND/OR INTRAMUSCULAR ROUTES DEVELOPED TUMORS AT THE INJECTION SITE. A SINGLE I.V. INJECTION OF THE CHEMICAL TO
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MALIGNANT TUMORS IN THE OFFSPRING. NO HUMAN EPIDEMIOLOGICAL DATA ARE AVAILABLE.
