ABSTRACT
IARC MONOGRAPH 31 JUL 83 TESTED IN MICE IN DIET, BY SKIN APPLICATION AND BY BLADDER IMPLANTATION AND IN RATS AND HAMSTERS BY SUBCUTANEOUS ADMINISTRATION. HEPATIC TUMORS INDUCED BY ORAL ADMINISTRATION IN BOTH MALE AND FEMALE MICE, ALTHOUGH INCREASED INCIDENCE SIGNIFICANT ONLY IN FEMALES. IN FEMALE RATSSIGNIFICANTINCREASEININCIDENCEOFFIDROSARCOMASAT SITE OF INJECTION; IN HAMSTERS INCREASED INCIDENCE OF SUBCUTANEOUS SARCOMAS. BLADDER CARCINOMAS OBSERVED IN FEMALE MICE AFTER IMPLANTATION OF PARAFFIN PELLETS CONTAINING TRP-P-1. STUDY IN MICE BY SKINPAINTING INADEQUATE.
