ABSTRACT

Evidence has been steadily accruing over time that a significant number of lipocalins interact with specific membrane receptors. The transfer of RBP:retinol across the cell membrane, faciliated by the elusive RBP receptor was for many years the archetypal example of a lipocalin.-receptor mediated process. Megalin was subsequendy identified as a low affinity/high capacity endocytic membrane receptor capable o f binding a range of lipocalins including RBP.