ABSTRACT
Domain Organization o f the CIP4 Family o f Proteins The hallmark o f the P C H proteins is the presence o f the Fes/CIP4 homology (FC H ) domain
o f around 60 amino acid residues. This domain is always found in association w ith a coiled-coil region (initially called a Cdc 15-like coiled-coil)1 and, for a long time, the biological role o f these domains was no t known (Fig. 1A). Importandy, two recent studies finally established the func tion o f the domains.8,9 These articles showed that the F C H and coiled-coil domains form a single unit and that they exhibit a significant similarity in secondary structure and function to the Bin/ Amphiphysin/Rvsp (BAR) domains, which are found in proteins in the endocytic pathway, proteins
such as endophilin and amphiphysin.6,7 This extended FCH domain has been referred to as either an FCH and BAR (F-BAR) domain or extended Fes/CIP4 (EFC) domain, but in the frame o f this article we will refer to it as F-BAR domain.
