ABSTRACT
Amongst the last vector-based hopes for malaria control the most touted one is, without doubt, the use of transgenic mosquitoes able to kill/ block the development of malaria parasites and thus to interrupt malaria transmission. This potential solution is gaining some support because of advances in our comprehension of mosquito immunity and technical progress allowing mosquito modification. If the lack of a genetic drive is a technical problem that can easily be solved thus allowing an allele of interest to spread in natural populations, the difficulties inherent in this method, its possible consequences and its validity for malaria con trol remain questionable.
