ABSTRACT
Eosinophils are normally seen in small numbers in the PB and show a slight diurnal variation that parallels that of cortisol levels, being lower in the morning and higher in the afternoon. Because they are present in such small numbers, some laboratories establish separate normal ranges depending on whether the count is automated or manual. Normal eosinophils are spherical with red cytoplasmic granules. The nucleus is usually bi-lobed, although occasional tri-lobed forms may be seen. Frequent tri-lobed forms or those with more lobes are abnormal and may become prominent in CM L, as are cells with hypogranulation or cytoplasmic vacuolization.
