ABSTRACT

M yeloid and erythroid maturation : Delineation of the myeloid and erythroid cells into specific stages of maturation is somewhat more problematic in the biopsy compared to the aspirate due to crowding of the cells, because the hematoxylin and eosin (H and E) stain is less well suited for highlighting features such as cyto­ plasmic granules and because the biopsy is examined using less magnification. For these reasons, the range of maturation is described in general terms and a formal differential cell count is not done. Range of maturation of each cell line can be de­ termined with practice. The imprecise process of differentiating early stage myeloid from erythroid cells, and blasts from slightly more mature cells (promyelocytes and myelocytes) can be aided by IH C stains.