ABSTRACT
T he haematopoietic system is a highly dynamic system where cell adhesion and cell migration are tightly controlled. D uring both embryonic and adult haematopoiesis, the finely orchestrated action o f several integrins contributes to the generation o f all different mature blood cells. W ithin the im m une system, integrins regulate cell-cell and
cell-extracellular matrix interaction during homeostasis as well as inflammation. Accumulating evidence suggests that many o f the integrin-mediated functions occur through physical inter action of integrins with other associated proteins. The goal o f this chapter is to describe the role o f integrins-particularly cc4, ß2, and ß7-and in tegrin-in teracting molecules in the haematopoietic and im mune systems.
