ABSTRACT
Toxoplasma gondii is a generalist both in its host range and choice of cell type. Virtually all warm-blooded vertebrates are susceptible hosts5 and within its host, all nucleated cells are subject to infection. T gondii is adept at entering and surviving in a variety o f leukocytes and both monocytes and dendritic cells are highly permissive for replication.6 Early studies estab lished that T gondii enters macrophages without stimulating a respiratory burst.7 The parasite establishes a vacuole that resist fusion with endosomes and lysosomes8,9 and which maintain a
Corresponding Author: L. David Sibley-Department of Molecular Microbiology, Washington University, St. Louis, Missouri 63130, U.S.A. Email: sibley@borcim.wustl.edu
Protozoans in Macrophages, edited by Eric Denkers and Ricardo Gazzinelli. ©2007 Landes Bioscience.
