Table 2

Table 2. Domain structure of enzymes of the six pseudouridine synthase families N-Terminal Forefinger Active Site Consensus Thumb C-Terminal

Name Extension Loop Sequence Loop Extension

TruD - - X A G X K D + -

TruA - + X X X R T D + -

TruB/Cbf5 - - H X G X LD + PUA domain

RsuA/RluE S4-like domain + X X G R L D - -

RluB/RluF S4-like domain + X X G R L D - CT domain

RluA - + X X H R L D + -

RluC/RluD S4-like domain + X X H R LD + CT subdomain

Pus10 THUMP domain + X X G RED + -

"X" indicates any amino acid. "+" and indicate the presence and absence of extensions or loops, respectively.