Skip to main content
Taylor & Francis Group Logo
    Advanced Search

    Click here to search products using title name,author name and keywords.

    • Login
    • Hi, User  
      • Your Account
      • Logout
      Advanced Search

      Click here to search products using title name,author name and keywords.

      Breadcrumbs Section. Click here to navigate to respective pages.

      Chapter

      p53 and the Proteasome Pathway
      loading

      Chapter

      p53 and the Proteasome Pathway

      DOI link for p53 and the Proteasome Pathway

      p53 and the Proteasome Pathway book

      p53 and the Proteasome Pathway

      DOI link for p53 and the Proteasome Pathway

      p53 and the Proteasome Pathway book

      ByWolfgang Hilt
      BookProteasomes: The World of Regulatory Proteolysis

      Click here to navigate to parent product.

      Edition 1st Edition
      First Published 2000
      Imprint CRC Press
      Pages 13
      eBook ISBN 9780429089206
      Share
      Share

      ABSTRACT

      I n agreement with the notion that selective protein degradation is involved in the regulation of m any cell regu latory processes, there is increasing evidence that deregulation of degradation can contribute to carcinogenesis. Many proto-oncogene pro­ ducts, for example c-jun , 1 are very short-lived and increases in their intracellu lar con­ centration can contribute to cellular trans­ formation indicating that the turnover rate of such proteins must be tightly controlled (for example see refs. 2-4). Indeed, in contrast to c-jun, the retroviral oncogene product v-jun is not targeted for degradation by the ubiquitin/proteasome system. 5 This results in increased levels of v-jun and, therefore, explains at least in part its transforming potential. 2’6 Another prominent example for the significance of selective turnover in cellular transformation is provided by the tumor suppressor protein p5 3 which plays a key role in human carcinogenesis. Activation of the growth suppressive properties of p 5 3 by appropriate stress signals, including genotoxic stress, is generally accompanied by intracellular accumulation of the protein. This suggests that stabilization of the otherwise short-lived protein is an intrinsic feature of p5 3 activation. In the following, the potential role of the ubiquitin/proteasome system in p5 3 degra­ dation and possible mechanisms involved in p 5 3 stability regulation will be discussed.

      T&F logoTaylor & Francis Group logo
      • Policies
        • Privacy Policy
        • Terms & Conditions
        • Cookie Policy
        • Privacy Policy
        • Terms & Conditions
        • Cookie Policy
      • Journals
        • Taylor & Francis Online
        • CogentOA
        • Taylor & Francis Online
        • CogentOA
      • Corporate
        • Taylor & Francis Group
        • Taylor & Francis Group
        • Taylor & Francis Group
        • Taylor & Francis Group
      • Help & Contact
        • Students/Researchers
        • Librarians/Institutions
        • Students/Researchers
        • Librarians/Institutions
      • Connect with us

      Connect with us

      Registered in England & Wales No. 3099067
      5 Howick Place | London | SW1P 1WG © 2022 Informa UK Limited