ABSTRACT
The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose up take in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regu lation of β-cell mass and function. This chapter summarizes current findings concerning the molecular mechanisms, downstream signaling pathways and critical components involved in regulation of β-cell growth and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promis ing molecules as a potential targets to induce proliferation and survival of β cells.
