ABSTRACT
The principles of the design of transition state analogues are discussed, illustrated with examples taken from the literature on catalytic antibodies. In the following discussion a number of imprinted polymer catalyst systems are described, including those cata lyzing elimination reactions, hydrolyses and carbon-carbon bond formation, with particular emphasis on the template in each case and how it relates to the transition state for the reaction studied. Finally the use of imprints as sites for carrying out chemical transformations with some control over the regiochemistry and/or stereochemistry of the reaction is described.
