ABSTRACT
A ntivirals Overview • A cyc lov ir • Va lacyclov ir • G anc ic lov ir • Va lgancic lov ir • Cytom egalovirus (CMV) Im m une G lobu lin • Foscarnet Sodium • C ido fov ir • Lam ivudine • A defovir D ip ivox il • O se ltam iv ir Phosphate
A ntibiotics Overview • T rim ethoprim and Sulfamethoxazole
(TMP-SMX) • Penicillins w ith Beta-Lactamase Inh ib ito r • Q u ino lones • Cephalosporins • Am inoglycosides • L inezolid • T igecycline • D aptom ycin
A ntifungals Overview • Nystatin Suspension • C lo trim azo le Troche • F luconazole • Posaconazole • Voriconazole • A m photeric in B • A m photeric in B Lipid C om plex In jection • M iconazo le Vaginal Cream 2% • Ketoconazole • Caspofungin • M icafungin • A n idu la fung in
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Acyclovir Mucosal and Cutaneous HSV Infection in Immunocompromised Patients • In adults, 5 mg/kg IV infused at a constant rate over 1 hour, every
8 hours (15 mg/kg/d IV) for 7 days • In children under 12 years of age, 10 mg/kg IV at a constant rate over 1
hour, every 8 hours for 7 days
HSV Encephalitis • In adults, 10 mg/kg IV infused at a constant rate over 1 hour, every
8 hours for 10 days • In children between 3 months and 12 years of age, 20 mg/kg IV at a
constant rate over 1 hour, every 8 hours for 10 days
Varicella Zoster Infection in Immunocompromised Patients • In adults, 10 mg/kg IV infused at a constant rate over 1 hour, every
8 hours for 7 days • In children under 12 years of age, 20 mg/kg IV at a constant rate over
_____________________1 hour, every 8 hours for 7 days_________________________________
Valacyclovir Herpes Zoster • 1 gram orally 3 times daily for 7 days
Genital Herpes • Initial episodes: 1 gram twice daily for 3 days • Recurrent episodes: 500 mg twice daily for 3 days
___________________ • Suppressive therapy: 0.5 -1 gram once daily_______________________
Ganciclovir Prevention and Treatment o f CMV in Transplant • 5 mg/kg IV given at a constant rate over 1 hour every 12 hours for
14 to 21 days • Followed by 5 mg/kg/d IV daily, or 6 mg/kg/d IV 5 days per week,
or 1000 mg orally three times daily • Duration of therapy depends on degree of immunosuppression; in
_____________________clinical trials, treatment was continued until postop day 100 to 120
Valganciclovir • Induction phase: 900 mg orally twice daily ___________________ • Maintenance phase: 900 mg once daily____________________________
Cytomegalovirus • 150 mg/kg within 72 hours of transplantation (CMV) Immune • 100 mg/kg at 2 ,4 ,6 , and 8 weeks posttransplant Globulin__________ • 50 mg/kg at 12 and 16 weeks posttransplant______________________
Foscamet Sodium Induction-Normal Renal Function • 60 mg/kg IV at a constant rate over a minimum of 1 hour every
8 hours for 2 to 3 weeks depending on clinical response
Maintenance-Normal Renal Function ___________________ • 90 mg/kg/d to 120 mg/kg/d IV infused over 2 hours_________________
C o n tin u e d ...
