ABSTRACT
In 1985 we observed that skin transplants given under cover of lytic anti-CD4 and CD8 monclonal antibodies (M abs) survived long-term even though peripheral T cells had returned to normal levels.1 In 1986 both we and David Wofsy demonstrated that short-term treatment with anti-CD4 Mabs could produce long-term tolerance to co-administered antigens.2'4 Subsequently it was shown that non-lytic CD4 antibodies were also able to induce tolerance.5' 10 Not only could CD4 Mabs impose this on a naive immune system, but also on animals that had previously been immunized, or on animals actively rejecting their grafts.
