Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) Pathway in Heart Disease

Abstract he JAK-STAT (Janus Kinases-Signal Transducers and Activators of Transcription) intra­ cellular signal transduction pathway plays a critical role in many human disease scenarios and especially in multiple aspects of the response of the myocardium to various cardiac

insults. The JAK-STAT pathway has immense potential impact on cardiovascular pathologies and represents a unique opportunity to control endogenous cardioprotective mechanism and as such offers an attractive therapeutic target for personalizing medicine.