ABSTRACT
A pregenomic functional paradigm came down to answers to the three following questions: 1. What is the biochemical function of the element (phosphatase? kinase? transcription
factor? etc.) 2. Which partners participate in the element functioning? 3. What is the physiological meaning of the molecular events in which the element is
involved? Attempts to answer these questions have relied upon the analysis of individual genes and
their role in specific cells or tissues. Genome analysis and parallel attempts to funcrionally annotate newly identified genes have lifted the curtain and revealed a tremendous complexity of functional organization of even simple genomic constituents. They appeared to be involved not in a single, but in multiple functions, sometimes even contrary, depending on the cellular state. The functions can be different in different tissues or at different stages of development and can be changed upon receiving specific signals by the cell. The problems of complexity are
Retroviruses and Primate Genome Evolution, edited by Eugene D. Sverdlov. ©2005 Eurekah.com.
