ABSTRACT
S o far it has seemed that estrogen is the primus inter pares o f an ever-growing number o f agents that control bone growth and strength in both women and, perhaps surprisingly, men (Baylink et al, 1999; Klein, 1999; Stevenson and Lindsay, 1999; Vanderschueren et al., 2000). Now it appears that bones are also the direct and indirect targets o f one o f the the principal operators o f the mechanism that was originally discovered managing the white fat energy reserves in mice (Ducy et al., 2000a,b; Fleet, 2 000 ; Himms-Hagen, 1999; Karsenty, 2000b ; S. Takeda et al., 2003) (Fig. 11).
