ABSTRACT
PMNs are the predominant cell type early on and migrate into the wound through an increase in vascular permeability and track along chemotactic gradients compro mised of cytokines, complement cascade products (C3a and C5a), and growth fac tors in a process called margination. Endothelial receptors called selectins help PMNs loosely adhere to the involved area before integrin receptors on the PMN allow firm interaction and allow subsequent migration between endothelial cells into the extra cellular matrix (ECM).
