Trauma and degeneration of orthopedic tissues are commonly associated with injuries to so tissues such as ligaments and tendon, which connect bone to bone, and muscle to bone, respectively. Given their inherent na noscale s tructural organization (Figure 2 .1), na notechnology-based t reatment mo dalities are actively being researched for the repair of these connective tissues. is chapter will highlight the current nanotechnology-based approaches in the treatment of injuries to tendons and ligaments, with an emphasis on the integrative repair, or biological xation, of these complex so tissues.