ABSTRACT
The application of mass spectrometry (MS) to protein and peptide characterization and sequencing has revolutionized the ‰eld and is essentially responsible for the overwhelming growth of the discipline of proteomics in the past decade. While the application of MS to characterization to nucleic acids is only beginning to be widely accepted, many of the techniques and approaches developed in proteomics have led to signi‰cant advances for the analogous approaches in the DNA world.
