ABSTRACT
Infrared spectroscopy (FTIR) is a well-established analytical technique for the characterization of a broad variety of products in the chemical and pharmaceutical industries. It is perhaps the most widely used method of applied spectroscopy for the positive identi‰cation of chemical compounds. In the speci‰c case of oligonucleotides, this technique can be used for the identi‰cation of the raw materials used during synthesis as well as identi‰cation of the drug substance. In practice, however, it is observed that mass spectrometry, base composition, and sequencing tend to be preferred for characterization of the drug product. In any case, the FTIR technique is available as a highly reliable approach for laboratories not equipped with mass spectrometry capabilities.
