ABSTRACT
A CRM design is completely specified by a set of design parameters. The first is the set of clinical parameters. These parameters are specified in accordance with the clinical objective, experimental setup, and practical constraints of the trial. Clinical parameters usually require inputs from clinical investigators, and may also be called clinician-inputparameters. Clinical parameters include the target toxicity probability θ , the number of test doses K, sample size N , the prior MTD ν0, and the starting dose of the trial x1.
