Potential Health Bene—ts of Orally Administered Hyaluronan in Alleviating Knee Joint Pain

Occurrence frequencies of osteoarthritis involving knee joint pain and in–ammation are rapidly increasing with a growing population of elderly in the United States and Japan. In the United States, it is reported that approximately 40% of the population 60 years and older has such symptoms, and approximately 10% of them have problems in their daily life [1].