ABSTRACT

Over the past decades, two-dimensional micropatternable nanobiomaterials with desired bulk and surface properties have attracted considerable attention, which has led to a wide range of applications in miniature biochemical sensors, engineered cellular microenvironments, and medical diagnostic microdevices (Zakhidov et al. 1998; Aizenberg et al. 1999; Shi et al. 1999; Cui et al. 2001; Veinot et al. 2002). A number of techniques have been demonstrated to prepare functional nanobiomaterials with topological micropatterns (De Rosa et al. 2000; Demers and Mirkin 2001; Chou et al. 2002; Loo et al. 2002; Whitesides and Grzybowski 2002), among which photolithography-based and so¹ lithography-based techniques have been the most popular choices. In comparison with so¹ lithography, direct photolithography techniques eliminate the extra molding step, resolve compatibility issues, and thereby, provide more e±cient rapid-prototyping processes to prepare a microstructured surface of functional nanobiomaterial. In this chapter, we present the recent development of photopatternable nanobiomaterials with particular emphasis on novel multifunctional micropatternable nanocomposites. Nanobiomaterials possessing a unique combination of photopatternability with the desired physical and chemical

28.1 Introduction ....................................................................................28-1 28.2 Photopatternable Conductive PDMS Nanocomposite

28.5 Future Perspectives .......................................................................28-12 References ..................................................................................................28-13

properties (such as conductivity, superhydrophobicity, antimicrobial and non-fouling properties, etc.) have demonstrated their extensive usage in the area of biosensors, bionics, and self-assembly.