ABSTRACT
Sleep and the immune system share regulatory molecules [1]. These molecules, mostly cytokines, are involved in both physiological sleep and the disturbed sleep observed during infection. It is feasible that sleep in—uences the immune system through the action of centrally produced cytokines that are regulated during sleep (see, for example, ref. [2]). In humans, both sleep and the neuroendocrine-immune system are controlled by a double-command system given by predictive and reactive homeostasis processes [3,4]. Predictive homeostasis is the primary role of the circadian system.
