ABSTRACT
In addition, melatonin contributes in the regulation of multiple pathophysiological processes, such as oxidation, tissue in—ammation, cancer, and apoptosis, and it has been proposed that it may act through the indirect regulation of gene expression. Thus, considering melatonin as an immune modulator agent with multiple anti-in—ammatory and antioxidant effects would seemingly favor its clinical application in some of these conditions. Further studies should also try to establish the bene£cial combination of antioxidants, as well as their doses, and the timing of administration. When such problems will be resolved, hopeful results about antioxidant therapy in critical illnesses will be more univocal and promising.
