ABSTRACT

Development ..................................................................................... 195 12.3 Mechanism Underlying the Proapoptotic Effect of P. urinaria ................... 196 12.4 The In Vivo Anticancer Effect of P. urinaria ............................................... 197

12.4.1 Phyllanthus urinaria Decreases In Vivo Angiogenesis in Tumor and CAM Assay ................................................................................ 198

12.4.2 P. urinaria Inhibited Angiogenesis-Related Functions of Vascular Endothelial Cells ............................................................... 198

12.4.3 Matrix Metalloproteinase 2 Activity Inhibited by P. urinaria Both In Vivo and In Vitro ................................................................. 199

12.5 Chemical Analysis of P. Urinaria ................................................................200 12.5.1 Ellagic Acid: The Major Compound in P. urinaria Exerts

Antiangiogenic Effect ....................................................................... 201 12.6 Conclusion .................................................................................................... 201 Acknowledgments ..................................................................................................202 References ..............................................................................................................202