ABSTRACT
Pharmacokinetics involves studying the kinetics of drug absorption, distribution, and elimination processes. These are the processes that dene the quantitative relationship between the administered dose of the drug and the drug concentration-time prole in different body ¥uids and tissues, while pharmacodynamics involves studying the quantitative relationship between the drug concentration at the site of action and the resulting therapeutic and/or toxic effects. It is obvious that these two disciplines are related because the drug concentration-time prole in the body ¥uids is related to the drug prole at the site of action, which in turn determines the intensity and the time course of the drug effect, as illustrated in Figure 19.1.
