ABSTRACT
As their name suggest, pluripotent stem cells can differentiate into the three germ layers and therefore have the potential to become any cell in the body, as demonstrated by the ability of iPSCs to generate viable mice (Boland et al. 2009). Whilst this property is highly desirable, and forms the basis of regenerative medicine it is a double-edged sword because any undifferentiated cells form teratomas (Hanley et al. 2010), especially when transplanted into syngeneic or immunocompromised recipients, such as those on immunosuppressive drugs.
