ABSTRACT
In order for the full potential of DPIs to be realized, it is essential to obtain high performance in terms of the reproducibility and efficacy of the drug respirable fraction. In this type of drug delivery system, the surface properties of the various components of both the powder formulation and the gelatin capsules, as well as environmental conditions, govern the physical properties of the aerosol cloud during inhalation. An improved fundamental understanding of particle adhesion to solid surfaces and to other particles is essential for enhanced control of the aerosol properties and, therefore, the respirable fraction.
