ABSTRACT
Disclaimer ...................................................................................................................................... 778 Introduction .................................................................................................................................... 778 Regulatory Response ..................................................................................................................... 779 Dietary Supplements for Weight Loss ........................................................................................... 779
Phenylethylamines .................................................................................................................... 779 Ephedra ................................................................................................................................. 781 Citrus aurantium .................................................................................................................. 781
Methylxanthines ........................................................................................................................ 781 Caffeine ................................................................................................................................ 782 Green Tea Extract: [From Camellia sinensis] ...................................................................... 782
Mitochondrial Uncoupling Agents ............................................................................................ 783 2,4-Dinitrophenol ................................................................................................................. 784 Usnic Acid ............................................................................................................................ 784 N-Nitrosofenˆuramine.......................................................................................................... 785
Vanilloid Receptor Agonists ...................................................................................................... 786 Capsaicin .............................................................................................................................. 786 Hoodia .................................................................................................................................. 786 Evodiamine ........................................................................................................................... 787
Other Mechanisms .................................................................................................................... 788 L-Carnitine ........................................................................................................................... 788 Chromium ............................................................................................................................. 789 Hydroxycitric Acid ...............................................................................................................790 Raspberry Ketone .................................................................................................................790 Acai Berry ............................................................................................................................ 791 Fucoxanthin .......................................................................................................................... 792 3,5-Diiodo-L-Thyronine ....................................................................................................... 792 Guggulipids .......................................................................................................................... 793 Mint, Cumin, Olive, Lady’s Mantle ..................................................................................... 793
Concluding Remarks ...................................................................................................................... 793 References ...................................................................................................................................... 794
The opinions expressed in this document should not be considered the ofcial regulatory position of the U.S. Food and Drug Administration (FDA), nor should any views or comments be considered reˆective of the current or future position of the FDA regarding any specic botanical mentioned. The mention of trade names does not constitute an endorsement by the FDA.
