ABSTRACT

Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA

3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45

3.2 Likelihood-Based Inference for Current Status Data . . . . . . . . . . . . 47

3.3 More General Forms of Interval-Censoring . . . . . . . . . . . . . . . . . . . . . . 58

3.4 Current Status Data with Competing Risks . . . . . . . . . . . . . . . . . . . . . 64

3.5 Smoothed Estimators for Current Status Data . . . . . . . . . . . . . . . . . . 71

3.6 Inference for Current Status Data on a Grid . . . . . . . . . . . . . . . . . . . . 77

3.7 Current Status Data with Outcome Misclassification . . . . . . . . . . . 79

3.8 Semiparametric Models and Other Work . . . . . . . . . . . . . . . . . . . . . . . . 80

Bibliography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

This chapter aims to revisit some of the important advances in the analysis

of current status data over the past decade. It is not my intention here to

be exhaustive because interest (and research) in current status has grown

46 Interval-Censored Time-to-Event Data: Methods and Applications

steadily in the recent past, and it would be difficult for me to do justice

to all the activity in this area in a chapter (of reasonable length) without

being cursory. I will concern myself primarily with some problems that are

closest to my own interests, describe some of the relevant results, and discuss

some open problems and conjectures. Before starting out, I would like to

acknowledge some of the books and reviews in this area that I have found both

enlightening and useful: the book on semiparametric information bounds and

nonparametric maximum likelihood estimation by Groeneboom and Wellner

(1992), the review by Huang and Wellner (1997), the review of current status

data by Jewell and van der Laan (2003), and last but not least, the book on

Interval-censoring by Sun (2006).