ABSTRACT
Department of Biostatistics and Epidemiology, Cincinnati Children’s Hospital
Medical Center, Cincinnati, Ohio, USA
4.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
4.2 Regression Analysis with Proportional Hazards Model . . . . . . . . . 93
4.3 Regression Analysis with Proportional Odds Model . . . . . . . . . . . . . 97
4.4 Regression Analysis with Linear Transformation Model . . . . . . . . 100
4.5 Bivariate Current Status Data with Proportional Odds Model . 101
4.6 Illustrative Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
4.7 Discussion and Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Bibliography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Current status data, which is also known as type I interval-censored data,
arise naturally in many applications including animal tumorigenicity experi-
ments, HIV and AIDS studies, demographic studies, econometrics, and epi-
demiological studies. In these studies, the variable of interest is the time to
the occurrence of a certain event, such as the tumor onset. By current status
data, we mean that each study subject is observed only at one time point and
92 Interval-Censored Time-to-Event Data: Methods and Applications
no information is available on subjects between their entry times and obser-
vation time points. In other words, for each subject, one only knows whether
the event of interest has occurred before the observation time.