ABSTRACT
Mitochondria were once free-living bacteria that had been acquired by the protoeukaryotic ancestor. This endosymbiotic event ultimately led to the full integration and adoption of mitochondria by the host cell, and mitochondria are now considered as essential cell organelles whose major functions lie in energy production, intermediary metabolism, and various other functions that are vital for the eukaryotic cell. Estimates of the size of the mitochondrial proteome vary, also depending on the organism in question, with an estimated 1,000 or so proteins in the yeast, Saccharomyces cerevisiae, to 1,500-2,500 proteins in mammals. Some of the conserved functions/pathways of mitochondria in nearly all respiring eukaryotes
12.1 Introduction ..................................................................................................245 12.2 Mitochondrial Protein Acetylation ............................................................. 247
12.2.1 Mitochondrial Acetylation Proteomics ........................................ 247 12.2.2 Bacterial Protein Acetylation .......................................................249 12.2.3 How Are Mitochondrial Proteins Acetylated? .............................250
