ABSTRACT

The exogenous administration of γ-hydroxybutyric acid (GHB), a putative neurotransmitter or neuromodulator of the central nervous system of mammals, has been reported to produce a number of pharmacological effects (for review see Vayer et al. 1987; Tunnicliff 1992; Cash 1994; Maitre 1997; Bernasconi et al. 1999). However, the majority of studies conducted to date have examined its effects at a cellular level, while there is a scarcity of systematic information concerning GHB behavioral effects.