The essence of a supply chain lies in its beauty and capability of its partners working as a “coherent whole” to reap the bene£ts of cooperation and coordination, though it is aptly said that a supply chain can be as strong as its weakest link. This signi£es the need and importance of building a strong, reliable, and robust supply chain. In a nutshell, the success or failure of any supply chain greatly depends on its structure and composition. Hence, restructuring of a supply chain is not a trivial issue; thus, the supply chain needs to be optimized, from time to time, to meet with market and customer requirements by embracing responsiveness. Therefore, the focus of this chapter is to introduce the importance of optimization in making a responsive supply chain.