ABSTRACT
In this chapter, we are focusing on three of these tools, which can handle both prokaryotic and eukaryotic genome annotations, as well as one tool that was speci¥cally designed for the annotation of microbial genomes generated using next-generation DNA sequencing methods. ™e examples described here are typical in their design and function for the class of static genome annotation systems. Various approaches to job management, data ¥ltering, and user interfaces in genome annotation are highlighted. ™ese design principles and concepts are also applicable to many other genome annotation tools that are not speci¥cally mentioned here.
