ABSTRACT
The CNS consists of highly differentiated cell types that include neural cells (i.e., Purkinje neurons, granule cells, motoneurons), glial cells (i.e., astrocytes, oligodendrocytes, ependymal cells, resident microglia), and endothelial cells that comprise part of the blood brain barrier (BBB). Unlike peripheral tissues, the CNS lacks resident natural killer cells, T and B lymphocytes, and has limited leukocyte extravasation across the BBB [3]. As such, major histocompatibility complex (MHC)
15.1 Central Nervous System Immunology.................................................................................. 199 15.1.1 Deœning Neuroinammation ....................................................................................200 15.1.2 PUFA Oxidation and Neuroinammation ................................................................ 201
15.2 Tocotrienol Vitamin E .......................................................................................................... 201 15.3 Arachidonic Acid Cascade in Neuroinammatory Disease .................................................203
