ABSTRACT
Introduction Phenothiazines constitute one of the largest chemical classes of organic compounds in o cial compendia. Over 4 thousands compounds have been synthesized and about 100 have been used in clinical practice [1]. 2,10-Disubstituted phenothiazines are very important drugs which are widely used in psychiatric treatment as tranquillizers. Invention and introduction of phenothiazine derivatives into treatment of mental disease has changed the modern psychiatry. is fact has improved the life style of patients and allowed quick development of ambulatory system of treatment for such sickness. e common use of phenothiazines has generated the need for fast and reliable methods for quality control of phenothiazine pharmaceuticals and monitoring them in clinical samples. Over fty years of the medical use of phenothiazines have resulted in countless number of analytical procedures devoted to resolve this problem [2, 3].
