Kinetics and Mechanism of Paracetamol Oxidation by Chromium(VI) in Absence and Presence of Manganese(II) and Sodium dodecyl Sulphate

Introduction Spectrophotometric determination of paracetamol in drug formulations has been the subject of several investigators [1-8]. Generally, the same principle, that is, oxidation of paracetamol by metal ion oxidants, has been used for the estimation of paracetamol. e ocial pharmacopeia [9] and Sultan [10] methods require a 60-minute reux period and 15 minutes heating of the reaction mixture, respectively. e main disadvantages of the Sultan method are that high concentration (6mol dm−3) of sulphuric acid and high temperature (80°C) are required for the oxidation of paracetamol by chromium(VI).