ABSTRACT
The success of any medicated topical nail formulation depends on its ability to deliver the medicament into and across the nail plate. Hence, preclinical evaluation of ungual and trans-ungual penetration of antifungal agents is an essential part of formulation development. Different experimental models have been used to evaluate the ungual penetration (drug transported into the nail plate) and permeation (drug transported across the nail plate) of drugs. This chapter outlines several experimental models or approaches, which have been used to characterize nail barrier properties, to evaluate perungual formulations, and to optimize drug delivery technologies.
