ABSTRACT
Parkinson’s disease (PD) is a clinicopathologic entity, characterized clinically by a variable combination of akinesia, rigidity, tremor and postural instability, and a characteristic pattern of neurodegeneration, affecting heavily not only dopaminergic neurons of the substantia nigra (SN) pars compacta but also many other brain areas. Eosinophilic protein inclusions of different shapes and localizations, called Lewy bodies (LBs) and Lewy neurites (LNs), are found and are generally considered to be an essential marker for the specic degenerative process underlying the disease and are therefore a hallmark for the pathologic diagnosis of PD.
