ABSTRACT
The use of therapeutic proteins originates in the 19th century, when polyclonal horse antitetanus and antidiphtheria immunoglobulins were used for the rst time. Then in the 1920s, bovine insulin and porcine insulin were introduced for the treatment of diabetes. Since then, insulin and many more protein drugs, including growth factor,
12.1 Introduction ..................................................................................................297 12.2 Immunogenicity as a Clinical Problem ........................................................ 298
12.2.1 Clinical Signicance of Unwanted Immune Responses ...................299 12.2.2 Examples of Immunogenicity ...........................................................300
