ABSTRACT
As discussed in the introductory chapter, Alzheimer’s can be portrayed as a calendar of events marked by increasingly devastating symptoms. By the time symptoms appear the brain has sustained such serious damage that it is dif€cult to imagine how to restore billions of dead neurons. The current wisdom is that with the long-term goal of managing or eventually curing AD, intervention must take place long before symptoms appear. For these reasons we choose to focus on possible early stages of AD with the recognition that initiation events are poorly understood.
