The three major essential nutrients, namely nitrogen (N), phosphorus (P) and potassium (K) have played a key role in expansion, sustenance and productivity of maize agroecosystem at large, in all the continents. On occasions, major nutrients have literally decided the nutrient dynamics and productivity levels of maize cropping belts. Major nutrients inherently contained in soil and that supplied through chemical and organic fertilizers, have of course influenced the maize-based cropping systems adopted by farmers. Maize cropping in dry lands and arable irrigated conditions, both are highly dependent on major nutrient supply. During recent years, research trends as well as farmers’ preferences have been to intensify maize production systems wherever feasible. This has necessitated adoption of improved soil fertility and crop management techniques. Fertilizer formulations and supply methods have consistently aimed at enhancing productivity levels and maximizing efficiency. Most suggestions aim at manipulating major nutrient dynamics in order to match nutrient needs of the maize crop at different growth stages. It is believed that such exact matching will improve fertilizer efficiency, grain/forage productivity and at the same time sustain optimum dynamics in soil. Currently we have maize production techniques that suit subsistence farming with low nutrient input. For example, consider dry lands of India, Pampas, Brazil, Southern, and Eastern Africa. Low levels of nutrient supply results in grain yield ranging from 2 to 4 t ha-1, at the most. In comparison, adoption of agronomic procedures like rapid soil tests, high nutrient inputs, split application, and proper placement of fertilizers have resulted in high productivity (8-10 t grain ha-1) within Corn Belt of USA, Northeast China or European plains produces. It is generally accepted that intensification of maize farming was achieved by modifying nutrient dynamics in soil and farm per se. Supplementing crop with irrigation and high density planting were other key procedures that rapidly converted moderately yielding farms into highly intensive agricultural zones. At this stage we have to appreciate that nutrient dynamics that ensues in maize cropping zones of the world varies enormously. Such variations are attributable to geographic location, its physiographic characteristics, soil types, inherent fertility status, cropping trends, maize genotype that dominates the agricultural landscape, human preferences and at times economics and legislations regarding cropping, irrigation, and fertilizer supply may all affect nutrient dynamics and productivity of maize agroecosystem.